Enfamil vs. Similac: What’s The Difference?


Enfamil vs. Similac

Pampers vs Huggies. Boudreaux’s Butt Paste vs. Dr. Brown’s. Even from Day 1, it can feel like buying baby products is a land mine of decisions. God forbid you don’t get the best detergent for cloth diapers! Choosing the right formula doesn’t have to be difficult. Here’s how to demystify the Enfamil Vs. Similac question.

The Main Difference

Both brands offer very similar options in their standard formula products for infants. When issues arise with your baby’s tummy, Enfamil seems to have more options than Similac. As with most things, finding out what your baby feels best with is a trial and error situation. Both brands dedicate themselves to solving issues with feeding your baby. Another thing to consider – once you find a formula that your infant seems to like, it may be best to just stick with it. While some mothers buy whatever’s on sale, you may decide “if it’s not broken, don’t fix it.” As always, please consult with your pediatrician before making your final decision.


Similac PRO-Advance is a good choice for those interested in something as close to breastmilk as possible. This standard formula includes human breastmilk prebiotics, which add immunity. The addition of DHA, Lutein and Vitamin E (a blend Similac refers to as Opti-GRO) helps overall growth and brain and eye development. Main ingredients include nonfat milk, lactose and whey protein concentrate. Meanwhile, Similac Advance is an identical product, minus the breastmilk prebiotics. It’s also important to note that Similac for Supplementation is identical to Similac Advance.


Similac’s Pure Bliss Infant Formula contains milk from grass-fed cows and is free of artificial growth hormones, GMOs and antibiotics. Main ingredients include nonfat milk and lactose. This is a good choice for those who place an importance on grassfed and non-GMO products. Parents interested in Similac’s more natural options also may like Similac Organic.

For babies with digestive issues, Similac Pro-Sensitive is for infants having issues with gas and mild spit-up. Its main ingredients include corn syrup and milk protein and the formula includes prebiotics.  Similac Soy Isomil, meanwhile, provides relief from excessive fussiness or gas. Its main ingredients include corn syrup solids and soy protein.


Enfamil Enspire most closely resembles Similac’s Pro-Advance formula – it includes prebiotics for immunity, Vitamin E and DHA (but not lutein). It’s also available in a non-GMO version. Main ingredients include nonfat milk and lactose. Meanwhile, Enfamil Newborn is great in the very beginning for young, sensitive tummies. It may require some trial and error until you settle on the right one, as Enfamil Gentlease is specifically marketed as a sensitive-tummy formula.

The Gentlease formula, which claims to provide 24-hour relief from gas and fussiness, consists mainly of corn syrup solids and partially hydrolyzed nonfat milk. In addition to aiding in digestive issues, it’s also used to transition babies from breastmilk to formula. For lactose intolerant babies, there’s Enfamil ProSobee, which consists of corn syrup solids and vegetable oil.

Is Store Brand Formula Any Good?

Good question! I started noticing that CVS was marketing its own formula. The container I saw said “Compare to Similac Advance.” So I did, and the ingredients and nutritional information are incredibly similar. So I asked my doctor and she gave me the go-ahead to use store brand if I prefer. I decided on my neighborhood H-E-B’s formula that closely resembles Similac Advance, which is what my daughter started on. For a 23.2 ounce tub, the cost is $13.98, compared to $25.94 for Similac.

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